Abstract
Background Children admitted to hospital with complicated severe malnutrition (CSM) have high mortality despite compliance with standard WHO management guidelines. Limited data suggests a relationship between intestinal dysfunction and poor prognosis in CSM, but this has not been explicitly studied. This study aimed to evaluate the role of intestinal disturbances in CSM mortality.
Abstract
Background
The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection and mortality. SM dysregulates the tryptophan-kynurenine pathway, which may impact
processes such as SIRT1- and mTORC1-mediated autophagy and mitochondrial homeostasis. Using a mouse and
organoid model of SM, we studied the repercussions of these dysregulations on malnutrition enteropathy and the protective capacity of maintaining autophagy activity and mitochondrial health.
The Childhood Acute Illness and Nutrition Network (CHAIN) is a multinational research group that aims to optimize the management and care of highly vulnerable children in resource-limited settings to improve survival, growth and development.
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