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CHAIN Publications

Rebalancing of mitochondrial homeostasis through an NAD+ – SIRT1 pathway preserves intestinal barrier function in severe malnutrition

By October 6, 2023No Comments


The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection and mortality. SM dysregulates the tryptophan-kynurenine pathway, which may impact
processes such as SIRT1- and mTORC1-mediated autophagy and mitochondrial homeostasis. Using a mouse and
organoid model of SM, we studied the repercussions of these dysregulations on malnutrition enteropathy and the protective capacity of maintaining autophagy activity and mitochondrial health.

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