The Childhood Acute Illness & Nutrition Network

A group of clinical experts, scientists and advisors worldwide seeking to optimize care for vulnerable children in limited resource settings


Child Health Task Force panel discussion on CHAIN with representatives from WHO, UNICEF & USAAID.

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CHAIN Results

The CHAIN cohort study found that young children in sub-Saharan Africa and South Asia who become sick or malnourished continue to have a high risk of death in the six months after being hospitalized.

To learn more about findings from the CHAIN cohort study, please visit:

Click Here to Read the full publication paper

Watch our CHAIN webinar “Childhood mortality during and after illness”:

On the Front line

We are delighted to share a new video created by our early career researchers and Al Davies called ‘On the Frontline’. It explores the idea of frontline researchers as a critical bridge between communities and research institutions and funders, offering important insights into the ethical dilemmas they face while also challenging simplistic generalisations about ‘vulnerable populations’ in the research context. Hats off to the team for adapting to the limits of lockdown around the world and lending their creativity and voices to this work! Please do share across your networks and feel free to use in teaching/training sessions:

The CHAIN Network is  focused on optimizing the management and care of the sick and undernourished child in  resource-limited settings to improve survival, growth and development.

The CHAIN Network aims to identify the biological mechanisms and the socio-economic factors that determine a child’s risk of mortality in the six months following presentation to medical care with an acute illness.

Clinical Sites

Partner Sites

Coordination Sites


The CHAIN Network aims to identify the biological mechanisms and the socio-economic factors that determine a child’s risk of mortality.

Recent Research

Inhibition of mTOR improves malnutrition induced hepatic metabolic dysfunction

| CHAIN Publications | No Comments
Abstract Severe malnutrition accounts for half-a-million deaths annually in children under the age of five. Despite improved WHO guidelines, inpatient mortality remains high and is associated with metabolic dysfunction. Previous…

Organoids as a model to study intestinal and liver dysfunction in severe malnutrition

| CHAIN Publications | No Comments
ABSTRACT Hospitalized children with severe malnutrition face high mortality rates and often suffer from hepatic and intestinal dysfunction, with negative impacts on their survival. New treatments cannot be developed without…

The Network will serve as a platform for substantive clinical trials that are led within the group in order to inform policy

The CHAIN Network is funded by the
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