A group of clinical experts, scientists and advisors worldwide seeking to optimize care for vulnerable children in limited resource settings
Recent Research
The first WHO Global Clinical Trials Forum was convened in November 2023 to develop a shared vision of an effective global clinical trial infrastructure. In this paper, the Paediatric Clinical…
Abstract Introduction Childhood illness and hospitalisation result in both direct and indirect costs to families before, during and after admission. We aimed to estimate the catastrophic expenditure during hospitalisation for children…
Children are not born equal in their likelihood of survival. The risk of mortality is highest during and shortly after birth. In the immediate postnatal period and beyond, perinatal events,…
Abstract Addressing the hurdles and opportunities associated with omics research in low- and middle-income countries may inform strategies for its effective execution, and thus increase our ability to tackle health…
Abstract Background Children admitted to hospital with complicated severe malnutrition (CSM) have high mortality despite compliance with standard WHO management guidelines. Limited data suggests a relationship between intestinal dysfunction and…
Abstract Background The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection and mortality. SM dysregulates the tryptophan-kynurenine pathway, which may…
Highlights
The CHAIN cohort study found that young children in sub-Saharan Africa and South Asia who become sick or malnourished continue to have a high risk of death in the six…
Child Health Task Force panel discussion on CHAIN with representatives from WHO, UNICEF & USAAID.
The CHAIN Network is focused on optimizing the management and care of the sick and undernourished child in resource-limited settings to improve survival, growth and development.
The CHAIN Network aims to identify the biological mechanisms and the socio-economic factors that determine a child’s risk of mortality in the six months following presentation to medical care with an acute illness.
Focus
CHAIN Burkina Faso site has been focused on the university of Ouagadougou newsletter. Read more…
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