CHAIN Network's Research


May 2, 2017 in featured, News

How best to detect malnutrition in infants under 6 months?

This is the question that CHAIN authors, Martha Mwangome, Moses Ngari, Jay Berkley and others have sought to answer in their new paper entitled “Diagnostic criteria for severe acute malnutrition…

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April 11, 2017 in featured, News

Sub-Study Feature: Enterics

The CHAIN Network Enterics Working Group led by Donna Denno, Judd Walson and Kirk Tickell, has identified three priority areas for investigation:

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September 1, 2016 in CHAIN Publications

Chronic disease outcomes after severe acute malnutrition in Malawian children (ChroSAM): a cohort study

AUTHORS: Natasha Lelijveld, Andrew Seal, Prof Jonathan C Wells, Jane Kirkby, Charles Opondo, Emmanuel Chimwezi, James Bunn, Robert Bandsma, Prof Robert S Heyderman, Prof Moffat J Nyirenda, Marko Kerac BACKGROUND: Tackling... Read More
August 29, 2016 in CHAIN Publications

Factors Associated with Klebsiella Bacteremia and Its Outcome in Under-Five Children Admitted with Diarrhea

AUTHORS: Akhter S, Ahmed T, Sarker SA, Sarmin M, Shahid AS, Shahunja KM, Islam SB, Shahrin L, Alam T, Alam NH, Chisti MJ Although Klebsiella bacteremia in children is perceived... Read More
August 2, 2016 in CHAIN Publications

Perceptions of childhood undernutrition among rural households on the Kenyan coast – a qualitative study

AUTHORS: Muraya KW, Jones C, Berkley JA, Molyneux S. BACKGROUND: Nutrition plays an important role in child survival and development. Treatment action in the management of child health and nutrition is... Read More
May 11, 2016 in CHAIN Publications

Nutritional status of children < 5 years of age who have a working mother: an epidemiological perspective of diarrhoeal children in urban Bangladesh

AUTHORS: Ferdous F, Das J, Ahmed S, Malek MA, Das SK, Faruque AS, Chisti MJ, Ma E, Wagatsuma Y OBJECTIVE: The present analysis aimed to observe nutritional impacts among children <5 years of age by mother‘s engagement in paid employment.... Read More
May 10, 2016 in CHAIN Publications

Impaired Bile Acid Homeostasis in Children with Severe Acute Malnutrition

AUTHORS: Ling Zhang, Wieger Voskuijl, Marialena Mouzaki, Albert K. Groen, Jennifer Alexander, Celine Bourdon, Alice Wang, Christian J. Versloot, Valeria Di Giovanni, Ronald J. A. Wanders, Robert Bandsma OBJECTIVE: Severe acute... Read More
May 3, 2016 in CHAIN Publications

Immune Dysfunction as a Cause and Consequence of Malnutrition

AUTHORS: Claire D. Bourke, James A. Berkley, Andrew J. Prendergast Malnutrition, which encompasses under- and overnutrition, is responsible for an enormous morbidity and mortality burden globally. Malnutrition results from disordered... Read More
May 2, 2016 in CHAIN Publications

Factors Associated with Streptococcal Bacteremia in Diarrheal Children under Five Years of Age and Their Outcome in an Urban Hospital in Bangladesh

AUTHORS: Shahid AS, Ahmed T, Shahunja KM, Kabir S, Chowdhury F, Faruque AS, Das SK, Sarker MH, Bardhan PK, Chisti MJ BACKGROUND: Although Streptococcal bacteremia is common in diarrheal children... Read More
April 16, 2016 in CHAIN Publications

Relations between Household Livestock Ownership, Livestock Disease, and Young Child Growth

AUTHORS: Mosites E, Thumbi SM, Otiang E, McElwain TF, Njenga MK, Rabinowitz PM, Rowhani-Rahbar A, Neuhouser ML, May S, Palmer GH, Walson JL OBJECTIVE: We assessed whether household livestock ownership or livestock disease episodes were associated with growth in young children in... Read More
March 4, 2016 in CHAIN Publications

Experience With Nosocomial Infection in Children Under 5 Treated in an Urban Diarrheal Treatment Center in Bangladesh

AUTHORS: Shahunja KM, Ahmed T, Faruque AS, Shahid AS, Das SK, Shahrin L, Hossain MI, Islam MM, Chisti MJ We aimed to evaluate the factors associated with nosocomial infections (NIs)... Read More
January 24, 2016 in CHAIN Publications

Hypernatremia in Children With Diarrhea: Presenting Features, Management, Outcome, and Risk Factors for Death

AUTHORS: Chisti MJ, Ahmed T, Ahmed AM, Sarker SA, Faruque AS, Islam MM, Huq S, Shahrin L, Bardhan PK, Salam MA We sought to investigate the magnitude, clinical features, treatment,... Read More
November 17, 2015 in CHAIN Publications

Carbohydrate malabsorption in acutely malnourished children and infants: a systematic review

AUTHORS: Kvissberg MA, Dalvi PS, Kerac M, Voskuijl W, Berkley JA, Priebe MG, Bandsma RH CONTEXT: Severe acute malnutrition (SAM) accounts for approximately 1 million child deaths per year. High... Read More
June 27, 2015 in CHAIN Publications

Fecal Markers of Environmental Enteropathy and Subsequent Growth in Bangladeshi Children

AUTHORS: Arndt MB, Richardson BA, Ahmed T, Mahfuz M, Haque R, John-Stewart GC, Denno DM, Petri WA Jr, Kosek M, Walson JL; in coordination with the MAL-ED Network Project Environmental enteropathy (EE),... Read More


August 23, 2016 in Background Publications

Treatment Failure and Mortality amongst Children with Severe Acute Malnutrition Presenting with Cough or Respiratory Difficulty and Radiological Pneumonia

AUTHORS: Chisti MJ, Salam MA, Bardhan PK, Faruque AS, Shahid AS, Shahunja KM, Das SK, Hossain MI, Ahmed T BACKGROUND: Appropriate intervention is critical in reducing deaths among under-five, severe acutely malnourished (SAM)children with... Read More
June 3, 2014 in Background Publications

Follow-Up of Post-Discharge Growth and Mortality after Treatment for Severe Acute Malnutrition (FuSAM Study): A Prospective Cohort Study

AUTHORS: Marko Kerac, James Bunn, George Chagaluka, Paluku Bahwere, Andrew Tomkins, Steve Collins, Andrew Seal BACKGROUND: Management of Severe Acute Malnutrition (SAM) plays a vital role in achieving global child survival targets. Effective treatment programmes are available... Read More
January 1, 2013 in Background Publications

Updates on the management of severe acute malnutrition in infants and children

AUTHORS: World Health Organization This guideline provides global, evidence-informed recommendations on a number of specific issues related to the management of severe acute malnutrition in infants and children, including in... Read More
April 1, 2012 in Background Publications

The effectiveness of interventions to treat severe acute malnutrition in young children: a systematic review

AUTHORS: Picot J, Hartwell D, Harris P, Mendes D, Clegg AJ, Takeda A BACKGROUND: Severe acute malnutrition (SAM) arises as a consequence of a sudden period of food shortage and is associated with loss... Read More
July 3, 2011 in Background Publications

Excess child mortality after discharge from hospital in Kilifi, Kenya: a retrospective cohort analysis

AUTHORS: Jennifer C Moïsi, Hellen Gatakaa, James A Berkley, Kathryn Maitland, Neema Mturi, Charles R Newton, Patricia Njuguna, James Nokes, John Ojal, Evasius Bauni, Benjamin Tsofa, Norbert Peshu, Kevin Marsh,... Read More