Forests
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Measurable results are the name of the game
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Kara LucasAnimal Activist
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Alexander GerardConversationalist
Free software tools for adaptive trial design
Adaptive trial designs have become popular in clinical trials and general randomized studies. They provide a number of advantages over traditional designs, e.g., adaptive designs support a variety of flexible decision rules aimed at identifying the best interventions or most promising populations of subjects in a data-driven way, and help improve the probability of success in the study.
A suite of free software tools (MedianaDesigner package) have been built to help research teams design complex adaptive trials. This package supports efficient simulation-based power and sample size calculations for most commonly used types of adaptive designs:
Adaptive trials with data-driven sample size or event count re-estimation.
Adaptive trials with data-driven treatment selection.
Adaptive trials with data-driven population selection.
The R package can be installed from the CRAN web site [https://cran.r-project.org/web/packages/MedianaDesigner/index.html]
Free web applications that facilitate simulation-based design of adaptive trials are available on the Cloud platform [https://cloud.mediana.us/login]. The applications can be accessed using the following login information:
Login: MedianaDesigner
Password: Rt5UKD8pzm
Additional information and multiple case studies can be found in the online manual [https://medianasoft.github.io/MedianaDesigner].
