CHAIN NETWORK

The Childhood Acute Illness & Nutrition Network

A group of clinical experts, scientists and advisors worldwide seeking to optimize care for vulnerable children in limited resource settings

Highlights 

African researchers training to develop large-scale genomics projects

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Child Health Task Force panel discussion on CHAIN with representatives from WHO, UNICEF & USAAID.

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The CHAIN Network is  focused on optimizing the management and care of the sick and undernourished child in  resource-limited settings to improve survival, growth and development.

The CHAIN Network aims to identify the biological mechanisms and the socio-economic factors that determine a child’s risk of mortality in the six months following presentation to medical care with an acute illness.

Clinical Sites

Partner Sites

Coordination Sites

 

The CHAIN Network aims to identify the biological mechanisms and the socio-economic factors that determine a child’s risk of mortality.

Recent Research

Intestinal disturbances associated with mortality of children with complicated severe malnutrition

| CHAIN Publications | No Comments
Abstract Background Children admitted to hospital with complicated severe malnutrition (CSM) have high mortality despite compliance with standard WHO management guidelines. Limited data suggests a relationship between intestinal dysfunction and…

Rebalancing of mitochondrial homeostasis through an NAD+ – SIRT1 pathway preserves intestinal barrier function in severe malnutrition

| CHAIN Publications | No Comments
Abstract Background The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection and mortality. SM dysregulates the tryptophan-kynurenine pathway, which may…
 

The Network will serve as a platform for substantive clinical trials that are led within the group in order to inform policy

The CHAIN Network is funded by the
All Partners